The surroundings are primarily forestland, one side of which is burnt, until it reaches CR 270, a bi-county east-west route in Liberty and Gadsden Counties.

Pine trees become more prominent after this and the next moderate intersection is with CR 1641 which spans southeast towards Hosford and northwest to Torreya State Park.

State Road 12 continues moving relatively northeast as it crosses the Liberty-Gadsden County Line and passes by the Poley Branch Church.

After SR 12 veers off to the right from Coleman Road it enters the City of Greensboro and then crosses an Apalachicola Northern Railroad line before curving back to the same direction.

Three and a half blocks later CR 270 turns north onto Tolar White Road and SR 12 continues as Selman Street.

As SR 12 curves back toward the east, it encounters another section of CR 270 (Bassett Road) and the eastern terminus of CR 270A (Flat Creek Road), just before a wye intersection with SR 65 (Hosford Highway) where the west end of concurrency with the route begins.

In Douglas City SRs 12/65 serves as the address for the Gadsden Correctional Facility, and then an at-grade crossing with the CSX Tallahassee Subdivision a line that carried the Amtrak Sunset Limited until it was truncated to New Orleans, Louisiana by Hurricane Katrina in 2005.

The Tallahassee Subdivision begins to move away from US 90/SRs 12/65, but almost comes back just before the intersection with CR 274 before entering Quincy where the concurrency becomes West Jefferson Street.

Between there it runs in front of the Gadsden County Courthouse and a block later at Madison Street, passes the former routing of SR 12.

Curving back to the east, the route runs past five churches then approaches CR 159 (Salem Road) where Havana Highway is changed to Ninth Avenue West.

Finally entering Havana the road crosses a CSX Railroad line and curves straight east just before the eastern terminus at US 27.

Upon leaving the town limits it becomes Fairbanks Ferry Road, where it curves more toward the northeast until it encounters the eastern terminus of CR 12B.