[4] State Road 145 begins in Madison at the southeastern terminus of the US 90/SR 53 overlap as Duval Street.

It runs for four blocks until the intersection of East Livingston Street, where it makes a sharp turn to the right.

The surroundings along SR 145 north of Madison are typical of most state and county two-lane roads along the Florida Panhandle, consisting of random farms and forests with occasional embankments over wetlands.

The other State Road 145 can be found in Fort Walton Beach, and has no connection to the SR 145 in Madison County.

The route begins at US 98 east of the wye intersection with SR 85 and west of the John T. Brooks Bridge.