It is a main east-west road in Southside Jacksonville, extending from an intersection with SR 13 (San Jose Boulevard) in the west to an interchange with I-295 in the east.

West of the western terminus, the road continues as a residential street, Holly Grove Avenue, heading toward the St. Johns River.

East of Florida State Road 13 it runs east-northeast over a bridge over Goodbys Creek, a tributary of the St. Johns that also ran beneath SR 13 south of that terminus.

East of that bridge, SR 152 serves as the border between two residential neighborhoods; Brierwood to the north and Craven to the south.

Shortly after its eastern terminus, Baymeadows Road turns north, and intersects Gate Parkway east of Exit 54 on I-295.