The highway connects the Florida state line, south of Clyattville with Wrightsville, via Valdosta, Douglas, and Dublin.

The highway was then incrementally extended in both directions from its resulting Pearson–Douglas segment to its current path.

The highway curves to the northwest and back to the north and passes Oris Blackburn Memorial Park.

It begins to curve to the northeast and enters Clyattville, where it meets the western terminus of SR 376 (Clyattville–Lake Park Road).

Approximately 1 mile (1.6 km) later, it skirts along the southeastern edge of Valdosta Regional Airport.

At the intersection with Madison Highway, it turns to the right and becomes known as Inner Perimeter Road, part of an eastern bypass of most of the city.

Then, it begins to curve to the north and enters the eastern city limits of Valdosta.

Along the eastern shore of Milltown Bay, they begin a northward routing and meet the western terminus of SR 31 Conn. (Murray Boulevard).

The other six highways continue to the east-northeast, crossing over Big Creek before leaving town.

Then, they pass Pine Forests Memorial Gardens and enter Douglas.

On the northern edge of town is an intersection with SR 206 Conn. (North Connector Road).

US 441/SR 31 curve to the northwest and enter Broxton, where SR 268 briefly joins the concurrency.

After they leave town, they continue to the northwest and have a short concurrency with SR 107, a few miles south of Jacksonville.

The three highways cross over the Ocmulgee River on the J. H. Millhollin Memorial Bridge, into Telfair County.

The five highways curve to the northeast and cross over the Little Ocmulgee River into Wheeler County.

They curve to the north-northeast, pass Oconee Fall Line Technical College, and enter Dublin.

Immediately is an interchange with I-16 (Jim Gillis Historic Savannah Parkway) and pass the Dublin–Laurens County Recreation Center.

In the central part of town, at an intersection with Martin Luther King, Jr. Drive, the three highways turn to the left onto South Monroe Street.

Also, SR 19 leaves the concurrency The five highways cross over the Oconee River on the Herschel Lovett Bridge, into East Dublin.

The concurrency enters Wrightsville and curve to the east to an intersection with SR 15/SR 57/SR 78 (Marcus Street).

[2][5] Between October 1929 and June 1930, the southern terminus of SR 31 was extended southwest to US 84/SR 38 east-northeast of Valdosta.

[21][22] In 1989, SR 822 was established from just south of the CSX railroad tracks in Dublin north-northwest to US 80/US 319/SR 26/SR 29/SR 31 (Bellevue Avenue).

It travels due east to meet its eastern terminus, an intersection with SR 135 (College Street).