It extends from SR 207 south-southwest of Spuds to SR A1A in Crescent Beach, two blocks west of the Atlantic Ocean.

SR 206 begins at an intersection with SR 207 in Spuds, near Deep Creek, a small tributary of the St. Johns River.

From there, SR 206 travels east through uninhabited farmland, crossing Interstate 95 (I-95).

SR 206 continues east through a partially established residential area before crossing the Intracoastal Waterway, entering Crescent Beach and terminating at SR A1A.

[2] The entire route is in St. Johns County.