The highway connects Northwest Florida Beaches International Airport with the rest of the Panama City–Lynn Haven, Florida metropolitan statistical area, as well as providing a major thoroughfare for commuters to travel around the north side of St. Andrews Bay.

The route travels east, crossing Crooked Creek on a bridge, before intersecting with the western segment of CR 388.

Continuing slightly northeast, it reaches a roundabout with another West Bay Parkway, the access road for Northwest Florida Beaches International Airport.

However, SR 388 was realigned onto a 4-mile-long (6.4 km) four-lane divided highway segment with bike lanes to the north, along with a roundabout being added to its intersection with the West Bay Parkway which leads to Northwest Florida Beaches International Airport, and a multi-use path on the south side of the road.

It begins at an intersection with SR 79 at the settlement of West Bay and runs east before turning northeast and terminating at an intersection with SR 388 slightly southwest of its roundabout with the West Bay Parkway that leads to Northwest Florida Beaches International Airport.