State Road 389 (SR 389) is a north–south highway carried by East Avenue in Bay County, Florida.

The southern terminus is at US 98 BUS (SR 30) in Panama City.

Before the late 1970s, the state-maintained portion actually continued south of its present terminus and dead-ended at the local paper mill.

Today, that portion of East Avenue is maintained locally.

This county-maintained stretch was signed as SR S-389 prior to the late 1970s.