The divided highway runs for about 0.19 miles (0.31 km) before transitioning to SR 442 just west of the I-95 interchange.

After the interchange, Indian River Boulevard continues east-northeast as a divided highway passing under a pedestrian bridge for the East Central Regional Rail Trail and intersecting Old Mission Road (CR 4137).

After spending its first two miles (3.2 km) in a more rural section of the city, the two roadway carriages come together and pass through a residential neighborhood of Edgewater.

SR 442 crosses a railroad and enters a more commercialized part of the city.

Media related to Florida State Road 442 at Wikimedia Commons