The highway then has an at-grade intersection with U.S. Route 441 (US 441; Orange Blossom Trail).

The highway then continues north as Vick Road.

The road originally would have been designated SR 429A, but it was changed to FL 451 in 2005.

In 2012, OOCEA (predecessor to CFX) announced the new designation, which took effect in January 2013.

[3] The entire route is in Apopka, Orange County.