Incumbent two-term Republican Governor Rick Scott was term-limited and could not run for a third term, and he successfully ran for Florida's Class I Senate seat.

Republican U.S. representative Ron DeSantis narrowly defeated Democratic mayor of Tallahassee Andrew Gillum for the governorship, in what some considered an upset.

[223] It was an hour long debate featuring topics like climate change,[224][225] minimum wage,[226][227] health care,[228] gun control,[229] the NRA,[230] DeSantis's "monkey up" comment[231] and President Donald Trump being a role model for children.

with Ron DeSantis and Gwen Graham with Ron DeSantis and Jeff Greene with Ron DeSantis and Chris King with Ron DeSantis and Philip Levine with Adam Putnam and Andrew Gillum with Adam Putnam and Gwen Graham with Adam Putnam and Jeff Greene with Adam Putnam and Chris King with Adam Putnam and Philip Levine with Bob White and Andrew Gillum with Bob White and Gwen Graham with Bob White and Chris King with Bob White and Philip Levine with generic Republican and Democrat with Richard Corcoran and Andrew Gillum with Richard Corcoran and Gwen Graham with Richard Corcoran and Chris King with Richard Corcoran and Philip Levine with Richard Corcoran and John Morgan with David Jolly and John Morgan with Jeff Atwater and Gwen Graham with Jeff Atwater and John Morgan with Pam Bondi and Gwen Graham with Pam Bondi and John Morgan with David Jolly and Gwen Graham with Andrew Putnam, Andrew Gillum, and John Morgan with Andrew Putnam, Gwen Graham, and John Morgan with Richard Corcoran, Andrew Gillum, and John Morgan with Richard Corcoran, Gwen Graham, and John Morgan with Adam Putnam and John Morgan DeSantis won 14 of 27 congressional districts.

[499] On November 10, 2022, former president Donald Trump claimed on his Truth Social page that he had prematurely ended the recount to prevent DeSantis and Senate candidate Rick Scott from losing, under the unsubstantiated belief that ballots for them were being removed.