In March 2008, a new 2.2 175 PS (128.7 kW; 172.6 bhp) TDCi common-rail diesel engine will be available on Mondeo providing acceleration to 0-60 mph (97 km/h) in 8.4 seconds on the saloon and fuel consumption of returning 45.6 mpg combined (this engine was replaced with the 2.0l TDCi 163 returning a combined 53.3mpg imp gallons,[clarification needed] with a marginal loss of performance).

[7] The new Mondeo uses the new electro-hydraulic steering system, first used on the C-Max, that sharpens the steering response, and helps to save fuel[8] Inside, the Mk IV features Ford's Human-Machine Interface (HMI) first seen on the Galaxy and S-Max whilst an enhanced instrument cluster featuring a 5-inch (130 mm) LCD for displaying trip computer and satellite navigation is available as an option on all models.

A product placement promotional initiative made the Mk IV Mondeo James Bond's car for one incidental scene in Casino Royale, introducing the new model to global audiences in November 2006, on the launch day of the movie.

As with the previous model, the Mk IV Mondeo was not marketed in the United States or Canada because Ford sold the same-class Fusion, which was launched in 2005.

The 2007 Mondeo marked the return to the Australian market after a six-year absence,[9] due to a resurgence in popularity of medium-sized cars in the last few years.

This is in no small part the result of high fuel prices making people reconsider purchasing large cars like the Ford Falcon.

The Mondeo was initially sold as a sedan and liftback body styles in the Australian market, with diesel or petrol engines, and in four trim levels: LX, TDCi, Zetec and XR5 Turbo.

In September 2010, a mid-cycle facelifted Mk IV Mondeo was introduced with some changes, such as the new ecoboost engines and LED daytime running lights.

The Irish range has the following trim levels: The Norwegian range has the following trim levels: The Mk IV Mondeo hosted features such as: Despite positive reviews from the motoring media right up to the final year of production, this generation of Mondeo has not been a strong seller in the United Kingdom, falling out of Top 10 Best Selling Cars In Britain in 2010, when just over 30,000 were sold, and plummeting to just over 16,000 sales in 2013, and less than 7,000 during 2014.