The invention in 1858 of rifled bores replaced Smooth-bore rifles, and extended the reach of projectiles to 2,500 m. Then melinite replaced gunpowder in 1885, which increased the blast of explosions, and forts of the Loyasse generation became obsolete.

Lyon acquired the land of the fort in 1949 at auction for 1,200,000 francs and used it as a roads department warehouse, a glacis, and allotment gardens still being cultivated today.

[2] The fort's underground galleries temporarily served as a mushroom farm.

A barracks of the fort was demolished in the 1960s to expand the Montée de l'Observance, a city street; the trenchwork of the fort allowed construction of a boulevard linking the new district of L'Observance to the Vaise neighbourhood in 1961.

A scene of the film Lucie Aubrac (1997) by Claude Berri has been linked to the fort de Loyasse.