Fourphit, also known as 4-isothiocyanato-PCP, is an irreversible dopamine transporter (DAT) blocker and a reversible NMDA receptor antagonist.

[1][2] It blocks the binding of methylphenidate to the DAT in vitro,[1] though apparently not in vivo.

[2] In any case, the drug reduces the stimulant-like effects of cocaine in animals,[2] whilst producing mostly negligible behavioral effects itself.

[2] Fourphit is an acylating derivative of phencyclidine (PCP) and a positional isomer of metaphit (3-isothiocyanato-PCP).

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