The film stars Belle Bennett, Henry Victor, June Marlowe, and Mary Carr.

Four years after their child's birth, Sonny (Wendell Phillips Franklin), Virginia, no longer wants to be a stay-at-home mom.

Virginia's mother-in-law, Mrs. Graham, played by Mary Carr, makes an offer to the couple.

After living awhile with Mrs. Graham, selfish Virginia becomes jealous of her mother-in-law's devotion to her son.

Virginia then sets her sights on her wealthy boss - Frederick Stoneman, played by Frank Elliott.

Shown below is the entry from the Catalog of Copyright Entries-Cumulative Series dated 1951 - THE FOURTH COMMANDMENT 1926 8 reels Credits: Story, Emilie Johnson(c) Universal Pictures Corp.; 14 Oct 26LP23239A report created by film historian and archivist David Pierce for the Library of Congress claims: Emory Johnson directed 13 films - 11 were silent, and 2 were Talkies.

The Fourth Commandment was the first film in Emory Johnson's eight-picture contract with Universal.