Francesco Acquaviva d'Aragona (14 October 1665 – 9 January 1725) was an Italian Cardinal, who served as ambassador of Spain to the Holy See.

[2] He obtained a doctorate in utroque iure, both canon and civil law from the University of Fermo.

In 1708, due to the Austrian conquest of the Kingdom of Naples, he lost a number of ecclesiastical benefices, but was compensated by Philip V with the appointment as diplomatic representative of the Catholic court to the Holy See, as well as cardinal protector of Spain.

[3] He was very loyal to Philip V, and sold his silverware to help the king bear the costs of the long war of succession and, in a critical moment, also saved the first wife of that sovereign, Luisa Maria Gabriella of Savoy.

He participated in matters such as arranging the marriage of King Philip V and Princess Isabella Farnese of Parma, on 20 August 1714.