[2] When Ferrante died in 1557 Ercole Gonzaga became guardian and the young Mantuan humanist and future Jesuit Antonio Possevino became tutor to the brothers.
Francesco's letters, almost always inspired by Cardinal Borromeo and revised and corrected by him, constituted an indirect means often used by the pope to communicate his decisions to Ercole Gonzaga.
In turn, the cardinal supplied his nephew, first from Mantua, then from Trento - where he had gone on 16 April 1561 to preside over the college of legates of the council -, suggestions, and advice and information.
On 16 July 1562 he opted for San Lorenzo in Lucina, a titular church declared to be a deaconry pro illa vice.
He opted for the order of cardinal priests on 1 March 1564 and San Lorenzo in Lucina was returned to its status as a titular church at that time.
The following month his brother Cesare, count of Guastalla, held an ornate commemoration in the Cattedrale di San Pietro apostolo in Mantua, including a large catafalque with an Egyptian motif.