Francesco Nerli, seniore (1594–1670) was a Roman Catholic cardinal.

[1] On 6 Jun 1650, he was consecrated bishop by Giovanni Giacomo Panciroli, Cardinal-Priest of Santo Stefano al Monte Celio, with Giovanni Battista Rinuccini, Archbishop of Fermo, and Luca Torreggiani, Archbishop of Ravenna, serving as co-consecrators.

[1][2] While bishop, he was the principal consecrator of Francesco Pannocchieschi d'Elci, Archbishop of Pisa (1663).

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