Caliendo hosted the show and performed in sketches in full makeup as characters he impersonated.

In some sketches, Caliendo impersonated multiple characters on screen at once, such as one spoofing a Seinfeld reunion show set in the future where he plays Jerry, George, Kramer, Elaine, and Newman; and another with Al Pacino and Robert De Niro as movie critics.

Caliendo's castmates from Mad TV, Aries Spears and Mo Collins, guest starred on the show.

Pat Kilbane and Pablo Francisco also guest starred but, they weren't on the show when Caliendo was.

TBS aired teaser commercials for the show during its coverage of Major League Baseball during the 2007 postseason.