Although the gameplay is similar to Qix, the backstory for Frenzy involves the player controlling a robot craft, attempting to capture deadly sub-atomic Leptons from inside a scientific research centre.

Chasers appear in higher levels which can collide with the player's robot craft, causing a life to be lost.

The player obtains an extra craft on completing the third, sixth and ninth screens.

It is stated in the instructions that a good strategy is to build narrow filled blocks using the faster speed across the centre of an unfilled area, and then finally seal the area off by using only the slower mode.

Also, in Frenzy, the Leptons move in a regular, completely deterministic pattern, and the player's robot craft is permitted to hesitate, making Frenzy a different playing experience to Qix.