He was the son of Frederick Francis I, Grand Duke of Mecklenburg-Schwerin, and Princess Louise of Saxe-Gotha-Altenburg.

Not long after Caroline's death, Frederick's court made known the late Landgravine's expressed wishes to her near relatives, who acted upon the matter.

Incidentally, four days later, on 7 April, Auguste's brother Frederick married Princess Elizabeth of the United Kingdom, daughter of George III.

Both of these marriages, featuring middle-aged couples, proved childless but extremely happy.

Auguste never remarried, remained in Mecklenburg-Schwerin for the rest of her life, and devoted herself to the care of her stepchildren.