Landgravine Auguste Fredericka of Hesse-Homburg (full German name: Auguste Friederike, Landgräfin von Hessen-Homburg; 28 November 1776, Bad Homburg vor der Höhe, Landgraviate of Hesse-Homburg, Holy Roman Empire[citation needed] – 1 April 1871, Ludwigslust, Grand Duchy of Mecklenburg-Schwerin was a German noblewoman.

Because all her older sisters married very early, Auguste became by 1793 in the primary caretaker of her parents, and a particular support to her ailing father.

In Homburg on 3 April 1818, the 41-years-old Auguste married Frederick Louis, Hereditary Grand Duke of Mecklenburg-Schwerin, twice a widower and father of four surviving children.

The marriage was suggested by the late second wife of the Hereditary Grand Duke, Princess Caroline Louise of Saxe-Weimar-Eisenach (Auguste's first-cousin) at her deathbed.

She developed a particularly close relationship with her stepdaughter Helene, second child and only daughter of her cousin Caroline Louise.