Fuller Albright

Fuller Albright (January 12, 1900 – December 8, 1969) was an American endocrinologist who made numerous contributions to his field, especially to the area of calcium metabolism.

The family was descended from Andrew Albright, a gunsmith who supplied arms to the troops of the Continental Army during the Revolutionary War, who had come to America in 1750.

While he initially took an interest in obstetrics and orthopedic surgery, the discovery of insulin attracted him to internal medicine, specifically the study of metabolism.

After his internship at Massachusetts General Hospital he embarked on a one-year programme of research with Joseph Charles Aub, mainly into calcium metabolism and lead poisoning.

He described polyostotic fibrous dysplasia (a version of this disease with an endocrine component was later eponymically called McCune–Albright syndrome), the clinical and pathological features and different types of hyperparathyroidism (excessive production of parathyroid hormone by the parathyroid glands), the mechanism of Cushing's syndrome, and renal tubular acidosis (inability of the kidneys to regulate the acid-base balance in the body), and recognized the importance of menopause on osteoporosis.

By 1956 his symptoms were so intractable that he underwent experimental brain surgery, chemical pallidotomy (obliteration of the globus pallidus by injection of alcohol).

The intervention on the right was a success, but the left-sided procedure was complicated by haemorrhage, which left him aphasic and comatose[clarification needed] for the remaining 13 years of his life, during which he was nursed at Massachusetts General Hospital.