54762207798ENSG00000178075ENSMUSG00000036292Q8IYS0Q8CI52NM_001172105NM_017577NM_001172107NM_153528NM_001359085NP_001165576NP_060047NP_001395265GRAM domain containing 1C also known as Aster-C is a cholesterol transport protein that is encoded by the GRAMD1C gene.

It is anchored to the endoplasmic reticulum through its transmembrane domain.

[7] When the plasma membrane contains high levels of cholesterol, GRAMD1c as well as GRAMD1a and GRAMD1b move to sites of contact between the plasma membrane and the endoplasmic reticulum.

[8] GRAMD1 proteins then facilitate the transport of cholesterol into the endoplasmic reticulum.

[7] The VASt domain is responsible for binding cholesterol while the GRAM domain determines the location of the protein through sensing of cholesterol and binding partially negatively charged lipids in the plasma membrane, especially phosphatidylserine.