One prominent analysis of the mouse gene predicts one form of Gramd1b that is 699 amino acids long.

The protein gets its name from the GRAM domain, located approximately 100 amino acids from the start codon.

The GRAM domain is commonly found in myotubularin family phosphatases and predominantly involved in membrane coupled processes.

[11] A C-terminal domain in GRAMD1B sits within the lumen of the ER, is predicted to have alpha-helical secondary structure,[12] and is modified by tryptophan C-mannosyaltion.

[17] A predicted leucine zipper pattern extends through a majority the transmembrane region though it is not a nuclear protein.

The EST profile is supported with experimental data from multiple sources[23] The ortholog space for GRAMD1B spans a large portion of evolutionary time.

[28][29] Mutations and other genetic studies link GRAMD1B to neurodevelopmental disorders, such as intellectual disability and schizophrenia.

[7] Loss of GRAMD1b results in reduced cholesterol storage in the adrenal gland and serum corticosterone levels in mice.

[7] A study tagging SNPs from chronic lymphocytic leukemia found GRAMD1B to be the second strongest risk allele region.

[30] This association is supported through a number of studies[31][32] The aberrant tri-methylation of histone H3 lysine 27 induces inflammation and has been shown to increase GRAMD1B levels in colon tumors.