[1] The main gallery and its annex are located in São Paulo, Brazil.

[3][4] The gallery opened in 1974, with an inaugural exhibition in the same year, with the participation of artists such as Carlos Fajardo, Edo Rocha, José de Moura Resende Filho, Luiz Paulo Baravelli, Nelson Leirner, Rubens Gerchman, Santuza Andrade, and Wesley Duke Lee.

[1][5] Galeria Luisa Strina was the first Latin American gallery to be invited to the art fair Art Basel, located in Basel, Switzerland, em 1992.

[2][6] In the 1990s, the gallery started working with Brazilian artists, such as Alexandre da Cunha, Fernanda Gomes and Marcos Reis Peixoto (known as Marepe).

[2] Currently, the gallery represents 40 artists, including:[2] In addition, the gallery manages various artist estates, including: The museum's directors are Marli Matsumoto and Thamy Echigo.