The Gambacher Kreuz (Gambach interchange) is a cloverleaf interchange in Hesse, Germany where the A5 Autobahn from Basel to Bad Hersfeld intersects the A45 between Dortmund and Aschaffenburg.

[1] It constitutes a node in the primary route between the Rhein-Main metropolitan area and the eastern end of the Ruhr valley.

The interchange is located between the villages of Münzenberg in Wetteraukreis to the south and Holzheim, a part of Pohlheim in Landkreis Gießen, to the north.

The Gambacher Kreuz was built when the A45 Dortmund-Gießen, also known as the Sauerlandlinie (Sauerland Line), was constructed.

It opened in 1971 as a trumpet interchange to the south and an incomplete junction to the north onto the A5.