She made one voyage under contract to the East India Company (EIC), and one in 1797 transporting convicts from England to New South Wales.

She was carrying rice on behalf of the British government, which was importing grain to address high prices for wheat in Britain following a poor harvest.

[3] Patrickson sailed Ganges from Portsmouth, England, in early 1797, and she arrived at Port Jackson on 2 June 1797.

[8] This was despite Sir James Fitzpatrick, the Home Department's surgeon-general, having ordered the installation of ventilators and water purifiers, and the stocking of fumigants and medicines.

[10] Lloyd's Register for 1799 shows Ganges, Patrickson, master, Captain and company as owners, and with trade London-Botany Bay.