García Álvarez de Toledo y Osorio, 4th Marquess of Villafranca del Bierzo (29 August 1514 – 31 May 1577), was a Spanish general and politician.
Among his many siblings was Eleonora of Toledo, wife of Cosimo I, Grand Duke of Tuscany.
In 1535, already the commander of six galleys, he distinguished himself in the battles of La Goletta, Tunis, Algiers, Sfax, Calibria y Mebredia.
As Viceroy of Sicily he accomplished his greatest achievement, the relief of the Siege of Malta (1565).
For this he received from King Philip II of Spain the titles Duke of Fernandina and Prince of Montalbán on 24 December 1569.