He collaborates with Stanford University professors Dr. William Barnett[4] and Dr. John Roberts to write and teach case studies on entrepreneurship, information technology, semiconductor industry, and the mobile internet.

In 1993, after working at Hewlett-Packard Company as a sales engineer, Mekikian joined the founding team at International Integration Inc., also known as i-Cube, which went public in 1998.

[21] Mekikian, along with a group of Armenian Americans, organized an event which was titled LA2DC,[22] a coast-to-coast, running and cycling, relay marathon.

Over a thousand athletes ran and cycled non-stop, from Los Angeles to Washington DC, to deliver a petition to Congress - a message of gratitude to Americans and others who worked to prevent genocides, and rescued the survivors.

Mekikian and colleagues authored the petition[23] which was delivered in a relay baton to Congressman Adam Schiff who read it on the floor of the House of Representatives on May 20, 2015.