GcvB enhances the ability of the bacterium to survive low pH by upregulating the levels of the alternate sigma factor RpoS.

[4] GcvB has been shown to regulate a large number of genes in E. coli and Salmonella species.

[5][6] It has been shown to also regulate gltL, argT, STM, livK, livJ, brnQ, sstT and cycA which are involved in uptake of a variety of amino acids.

[10] GcvB RNA binds PhoPQ mRNA, which encodes a two-component system involved in magnesium homeostasis.

Native polyacrylamide gel electrophoresis was used to show a higher molecular weight band corresponding to a potential polymer.