Gelesis100, sold under the brand name Plenity, is an oral hydrogel used to treat overweight and obesity.
[1] It absorbs water and expands in the stomach and small bowel thereby increasing feelings of fullness.
[6][7] Gelesis100 has been criticized for its small impact on weight loss relative to side effects.
[1] Taken in capsule form by mouth,[10] as Gelesis100 absorbs water, it expands in the stomach and small intestine.
[3][6] After absorbing water, a semisolid gel structure forms, which may promote satiety and result in weight loss[1] via reduced caloric intake.