Oxyntomodulin (often abbreviated OXM) is a naturally occurring 37-amino acid peptide hormone found in the colon, produced by the oxyntic (fundic) cells of the oxyntic (fundic) mucosa.
[2] Oxyntomodulin could be a potential candidate for treating obesity because of its ability to suppress appetite.
[3] In a 4 week study, healthy overweight and obese volunteers were given either saline or oxyntomodulin injections.
Their body weight, energy intake, and the levels of adipose hormones were taken prior to the treatment.
In the course of 4 weeks, volunteers treated with oxyntomodulin injections had an average weight loss of 2.3±0.4 kg compared to those treated with saline who had an average of 0.5±0.5 kg, indicating oxyntomodulin was successful in weight loss.