Genazzano is a town and comune in the Metropolitan City of Rome, located on a tuff spur at 375 metres (1,230 ft) above sea level that, starting from the Monti Prenestini, ends on the Sacco River valley.

In the fifth century, during the reign of Pope Sixtus III, the town of Genazzano contributed a large portion of its revenue for the Roman basilica of Santa Maria Maggiore.

In the 11th century AD it was a fief of the Colonna family who, from their baronial Palace (castle), controlled the road from Naples to Rome.

The church of the Madonna del buon consiglio, built in appreciation for the town's contribution to Santa Maria Maggiore, and entrusted in 1356 to the Augustinian Order, holds the original fresco of Our Lady of Good Counsel (Latin: Mater boni consilii) a title given to the Blessed Virgin Mary, after the miraculous fresco.

On the southern slopes of Monti Prenestini overlooking the Valle del Sacco is the Genazzano Denominazione di origine controllata (DOC) region that produces both red and white wines.