Located near the Monti Sabatini, at the feet of an extinct volcano, it is included in the Regional Park of Veii.

They were originally part of the territory of the Etruscan city of Veii.

A castle was built here probably in the 10th-11th century; in the 13th century it was a possession of the Prefetti di Vico, and later of the Savelli and the Orsini, who acquired it under the reign of Pope Gregory XI (1370–1377).

Apart a short conquest by Cesare Borgia (1503–1516), they kept Sacrofano for nearly three centuries: in 1560 it was included in the Duchy of Bracciano.

It can be reached by car from Rome in c. 20 minutes through the Via Flaminia and the Via Sacrofanese.