Riofreddo is a comune (municipality) in the Metropolitan City of Rome in the Italian region Lazio, located about 45 kilometres (28 mi) northeast of Rome.

It was an ancient Roman fortress guarding the ancient Via Valeria of which a few sections remain with the typical Roman paving and a bridge attributed to the Emperor Nerva.

It also preserves three necropolises, the most interesting and oldest dating to 1000 BC.

Riofreddo borders the following municipalities: Arsoli, Cineto Romano, Oricola, Roviano, Vallinfreda.

The Oratorio della Santissima Annunziata contains early 15th-century frescoes.