Gene-Ann Polk Horne (October 3, 1926 – January 3, 2015), known professionally as Gene-Ann Polk, was an American physician and hospital administrator, director of pediatric ambulatory care at Harlem Hospital, and a professor of pediatrics at Columbia University.

[8] Polk had a long career at Harlem Hospital, from 1953 when she began her residency,[9] to her retirement in 1994.

[10] She was a professor of clinical pediatrics at Columbia University's College of Physicians and Surgeons from 1962 to 1994.

[5] Gene-Ann Polk married oral surgeon Edwin Clay Horne.

She died from pancreatic cancer[15] in January 2015, aged 88 years, at her home in Lafayette Hill, Pennsylvania.