Towards the end of the 19th century, Dr. Eduardo Liceaga proposed the construction of a new hospital to fulfill the sanitary needs of the city.

The General Hospital began its construction in 1896, with a total budget for the project of four million eight thousand pesos, and was inaugurated on February 5, 1905, by president Gral.

The 1985 Mexico City earthquake damaged the Gynaecology Unit, and the Medical Residence tower was completely destroyed.

More than 295 people died, including patients, residents, and medical staff.

Researchers from the hospital found that classical music composed by Mozart had a positive effect on heart disease.