Georg Karl Frederick (24 July 1796 in Hildburghausen – 3 August 1853 in Hummelshain) was Duke of Saxe-Altenburg from 1848 to 1853.

He was the fourth but second surviving son of Frederick, Duke of Saxe-Hildburghausen (of Saxe-Altenburg from 1826) and Duchess Charlotte Georgine of Mecklenburg-Strelitz.

He fought in the Austrian ranks against Napoleonic France in the 1813–1814 war.

Georg succeeded his brother Joseph as Duke of Saxe-Altenburg when he abdicated, in 1848.

In Ludwigslust on 7 October 1825 Georg married with Duchess Marie Louise of Mecklenburg-Schwerin.