It heads north through town to an intersection with SR 38 Spur (1st Avenue NE).

It continues north to meet US 84/SR 38, before leaving Cairo.

It stair-steps its way to the northeast to meet SR 3 Alternate (Main Street) in Ochlocknee.

In Coolidge, the highway intersects US 319/SR 35 (Pine Street).

[1] SR 188 is not part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility.