According to the Georgia Department of Economic Development, Southwest Georgia consists of the following counties: Baker, Calhoun, Colquitt, Decatur, Dougherty, Early, Grady, Lee, Miller, Mitchell, Seminole, Terrell, Thomas, and Worth.

In a separate study by the American Community Survey, the counties forming the Southwest Georgia Regional Commission had a collective population of 347,714 in 2022.

In terms of religious belief and observance, Southwest Georgia is a part of the largely evangelical Protestant Bible Belt.

Following, nondenominational Protestants numbered 21,710, according to the Association of Religion Data Archives.

[4][5][6] Throughout each subdivision of Southwest Georgia, an estimated 24.5% to 25% of the population lived at or below the poverty line.