The only portion of SR 33 that is part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility, and defense, is the entire length of the US 319 Bus.

[3][4] By October 1926, the segment of SR 33 from Thomasville to Moultrie was shifted eastward to SR 35's former path from the Florida state line to Quitman, and then from Quitman north-northwest and northwest to Moultrie.

The northern terminus of SR 33 was extended on its proposed path, from Sylvester to the Cordele area.

[6][7] In the first quarter of 1937, the entire length of SR 33 that existed at the time had a "completed hard surface".

[14][15] Between September 1953 and June 1954, the entire extension of SR 133, from Boston to Moultrie, was hard surfaced.

Its former segment was redesignated as SR 333, from the Florida state line to north of New Rock Hill, and an eastern rerouting of SR 133, from north of New Rock Hill to Moultrie.

It continues to the east-northeast and crosses over some railroad tracks of Norfolk Southern Railway.

At an interchange with I-75, SR 33 Conn. ends, and Rockhouse Road continues to the east-northeast.