The highway heads to the southeast, into Lyons, It parallels US 280/SR 30 along the way.

Just past SR 86, the route crosses the Ohoopee River, where it enters Tattnall County.

Farther to the southeast, in the city of Collins, is an intersection with SR 23/SR 57/SR 121.

The route continues east through Manassas and enters the city of Bellville.

Just east of Bellville, SR 292 meets its eastern terminus, an intersection with US 280/SR 30.