It connects Clyattville with the Statenville area, via Lake Park.

The route continues to the east-northeast and enters the western part of Lake Park, where it intersects US 41/SR 7 (West Marion Avenue).

The three highways travel concurrently into the main part of town, where SR 376 splits off to a generally east-northeastern direction.

It travels through rural areas of Echols County, and crosses over the Alapahoochee River, until it meets its eastern terminus, an intersection with SR 135 west of Statenville.

[4] The road that would eventually become SR 376 was built between 1957 and 1960 along the same alignment as it travels today.