The roadway was built in the late 1950s and was designated as SR 377 in the mid-1970s.

It heads northwest, and curves to the north-northwest, to an intersection with SR 118, east of Smithville.

The route continues to the north-northwest, crossing into Sumter County along the way, and meets its northern terminus, two intersections with US 280/SR 27/SR 30/SR 49, on one-way pairs, in Americus.

The highway roughly parallels US 19/SR 3 for nearly its entire length.

[1] SR 377 is not part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility.