The route connects the Morgan area to Moreland, via Buena Vista, Manchester, Warm Springs, and Greenville.

After that, it curves to the due north and crosses over Juniper Creek into Talbot County.

Just over four blocks later, SR 41 departs to the north on Washington Avenue and then crosses over Lazer Creek.

The concurrency curves to the northwest and meet the western terminus of SR 85 Spur (Perry Street).

On the northwestern edge of town, they meet the southern terminus of SR 173 (Raleigh Road).

They continue to the northwest and enter Warm Springs, where they intersect SR 85 Alternate (Whitehouse Highway).

Right after passing the Roosevelt Memorial Golf Course, they meet the eastern terminus of SR 194 (Durand Highway).

In Harris City, the two highways pass Phillips Lake and intersect SR 18, which joins the concurrency.

US 27 Alternate/SR 41 continue to the north-northwest and pass through rural areas of the county and enter Luthersville.

The two routes pass through rural areas of the county and intersect US 29/SR 14 on the southeastern edge of Moreland.

At this intersection, SR 41 meets its northern terminus, while the other three routes continue to the north-northwest into Newnan.

The section from Talbotton to south of Geneva was listed as "graded, but unsurfaced," before paving started again approximately 10 miles north of Buena Vista.

The section from south of Buena Vista to Cuthbert was listed as unimproved but maintained.

The last available highway map dates to January 1942 and shows the southern terminus extended to Morgan with the same road surface as 1940.

By 1950, the road was realigned away from Cuthbert and ran from Preston to Weston and then directly to Morgan.

The highway heads nearly due north until it meets its northern terminus, an intersection with SR 41/SR 137.