It travels from the northwestern corner of Columbus northeast to just before Shiloh, north to Greenville, and northwest to Carrollton.

It then enters Meriwether County, running along the southeastern edge of F. D. Roosevelt State Park while briefly crossing SR 190 and curving from the northwest to the northeast.

US 27 Alt./US 29/SR 14 serves as the main road through downtown Moreland, and, after passing by the Lewis Grizzard Museum,[2] the Atlanta and West Point Railroad (AWP) main line moves to the west side of the road at a powerline right-of-way.

It curves away from the tracks again at the intersection of "Old Highway 29", and, after winding around the northwestern edge of Newnan–Coweta County Airport, Interstate 85 (I-85) is encountered at a diamond interchange (exit 41).

It also runs along both sides of the historic Coweta County Courthouse between Broad and Washington streets.

As US 27 Alt./SR 16/SR 34 moves from Clark Street to Temple Avenue, they begin to head northwest out of Newnan, only for SR 34 to leave that concurrency at Franklin Road.