[9] Throughout training camp, Pratt competed with Hardy Nickerson, Malik Jefferson, Deshaun Davis and Noah Dawkins for a role as the Bengals' primary backup linebacker, resulting in Pratt winning the job, and head coach Zac Taylor placing him behind starters Preston Brown, Nick Vigil, and Jordan Evans on the depth chart to begin the regular season.

In Week 10, Pratt started at middle linebacker, replacing Brown, and made four combined tackles (three solo) in the Bengals' 49–13 loss against the Baltimore Ravens.

On November 12, 2019, the Cincinnati Bengals waived Preston Brown, subsequently resulting in Pratt remaining as the starter for the remainder of the season.

Pratt made an interception in Week 9 against the Carolina Panthers, leading to a viral celebration by the entire Bengals defense, doing snow angels in the end zone.

[19][20] In the Bengals' Week 1 game against the Cleveland Browns, Pratt recorded his second career sack and force a fumble in the 24–3 loss.

[21] Pratt made an interception in Week 5 against the Arizona Cardinals, but suffered a minor shoulder injury while bringing the ball in.