German Run is a tributary of Little Muncy Creek in Lycoming County, Pennsylvania, in the United States.

It then turns southwest for several tenths of a mile, receiving one unnamed tributary from the left and one from the right before entering Moreland Township.

An unnamed distributary then branches off, quickly joining Little Muncy Creek, while German Run itself turns south-southwest for several tenths of a mile, receiving another unnamed tributary from the left, before turning north and then west, quickly reaching its confluence with Little Muncy Creek.

[6] A concrete tee beam bridge carrying State Route 2019 over German Run was built in 1937 7 miles (11 km) east of Clarkstown and is 26.9 feet (8.2 m) long.

A concrete slab bridge carrying State Route 2015 was constructed across the stream 1.5 miles (2.4 km) south of Lairdsville in 1949 and is 22.0 feet (6.7 m) long.

A concrete culvert bridge carrying State Route 2019 across German Run was constructed in 2009 5 miles (8.0 km) east of Clarkstown and is 24.9 feet (7.6 m) long.

received a permit to build, maintain, and operate a 12-inch (30 cm) natural gas pipeline crossing several unnamed tributaries of German Run.