Jakes Run is a tributary of Little Muncy Creek in Lycoming County, Pennsylvania, in the United States.

It then turns south-southeast again for a few tenths of a mile, entering Moreland Township and passing near Ball Ridge.

The stream then continues flowing south-southeast for more than a mile along the eastern side of Ball Ridge.

[1] Jakes Run joins Little Muncy Creek 12.84 miles (20.66 km) upstream of its mouth.

[4] Jakes Run was entered into the Geographic Names Information System on August 2, 1979.