The AP courses offered at GHS consist of Psychology, United States History, Microeconomics, Macroeconomics, European History, AB and BC Calculus, Statistics, Biology, Chemistry, Physics, English Literature, English Language and Composition, and Music Theory.

Germantown High also sponsors other activities, such as yearbook, Environmental Club, Key Club, German Honor Society, Spanish Honor Society, Battle Bots, FRC Robotics Team 5096, Wall of Sound (Germantown's competitive marching band), Pep Band, FBLA, DECA, and Student Council.

[2] The school competes in the Greater Metro Conference, and offers the following sports:[3] The football team had undefeated seasons in 1973 and 1974.

Germantown won its first Wisconsin Interscholastic Athletic Association Division 1 basketball state championship in 2012, beating Milwaukee King 72 to 69 in the title game.

[4] The school won their second consecutive WIAA Division 1 basketball state championship in 2013, defeating Mukwonago 57-28, after a second undefeated season.